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#Oxygen not included download build 210489 pdf

RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound P()()=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 30.

208000009292 Hemophilia A Diseases 0.000 claims description 30.

229920001850 Nucleic acid sequence Polymers 0.000 claims description 37.

239000008194 pharmaceutical composition Substances 0.000 claims description 39.

230000002401 inhibitory effect Effects 0.000 claims description 77.

230000014509 gene expression Effects 0.000 claims description 88.

150000002632 lipids Chemical class 0.000 claims description 92.

125000003729 nucleotide group Chemical group 0.000 claims description 295.

239000002157 polynucleotide Substances 0.000 title claims description 379.229920000023 polynucleotide Polymers 0.000 title claims description 379.239000003795 chemical substances by application Substances 0.000 title claims description 499.

Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from US201462072686P external-priority Application filed by Genzyme Corp filed Critical Genzyme Corp Priority to EP21158656.5A priority Critical patent/EP3904519A1/en Publication of EP3212794A2 publication Critical patent/EP3212794A2/en Application granted granted Critical Publication of EP3212794B1 publication Critical patent/EP3212794B1/en Status Active legal-status Critical Current Anticipated expiration legal-status Critical Links Original Assignee Genzyme Corp Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) ( en Inventor Gregory Hinkle Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active Application number EP15795074.2A Other languages German ( de)

#Oxygen not included download build 210489 pdf

Google Patents Polynucleotide agents targeting serpinc1 (at3) and methods of use thereofĭownload PDF Info Publication number EP3212794B1 EP3212794B1 EP15795074.2A EP15795074A EP3212794B1 EP 3212794 B1 EP3212794 B1 EP 3212794B1 EP 15795074 A EP15795074 A EP 15795074A EP 3212794 B1 EP3212794 B1 EP 3212794B1 Authority EP European Patent Office Prior art keywords agent nucleotides antisense polynucleotide serpinc1 nucleotide Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents EP3212794B1 - Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof EP3212794B1 - Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof